NZ-97 is an inhibitor for dipeptidyl peptidase 4 ( DPP4 ) with an IC 50 of 18 nM. NZ-97 exhibits a low initial plasma exposure with C max of 0.13 µM, which is eliminated in 8 h. NZ-97 ameliorates damage in the Lipopolysaccharides -induced lung injury and Bleomycin -induced lung fibrosis in mice model.