NMS-P626 is an inhibitor of TRKA , TRKB , and TRKC , with IC 50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC 50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research.