Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC 50 of 0.090 µM and a K d of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer ( NurRE , EC 50 =0.094 µM) and the Nurr1-RXR heterodimer ( DR5 , EC 50 =0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable.