BioReagent 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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本系列荧光纳米颗粒是 DSPE-PEG₂₀₀₀包覆聚集诱导发光（AIE）分子而得，AIE 分子嵌入在纳米颗粒 内部，由于聚集诱导发光特点，聚集时不会发生荧光猝灭效应，能够大幅度地提高 AIE 分子的荧光效率； 本系列纳米颗粒单分散性良好，粒径均一；AIE 分子被 DSPE-PEG₂₀₀₀包裹后，隔绝了外界环境对其影响， 荧光稳定性大大提高，荧光效果持久稳定；本系列纳米颗粒为近红外荧光纳米颗粒，适用于小动物活体成 像，具有组织穿透性强、水溶性好、生物毒性低等特点。同时，我们可提供不同粒径和具有功能性基团的微球，能够满足客户多样化的需求。
产品规格及参数
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产品成像步骤
- 步骤如下
- 实验准备：准备 5 周龄的 Balb/c 雄性裸鼠，注射肿瘤细胞株系（1×10⁶/0.1ml）于 Balb/c 雄性裸鼠皮下或 尾静脉等部位。
- 当肿瘤体积长到 60-80mm³ 时，对裸鼠成像，作为对照。
- 动物成像实验：尾静脉注射 0.2ml（1mg/ml AIE NPs）近红外荧光微球到裸鼠体内，之后对裸鼠成像。
产品应用场景
实例一：肿瘤成像
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实例二：血管成像
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本方案仅供参考，具体实验条件请研究人员依据自身项目进行优化。
This series of fluorescent nanoparticles are obtained by coating aggregation-induced emission (AIE) molecules with DSPE-PEG₂₀₀₀. The AIE molecules are embedded inside the nanoparticles. Due to the characteristics of aggregation-induced emission, there is no fluorescence quenching effect during aggregation, which can greatly improve the fluorescence efficiency of AIE molecules.
This series of nanoparticles have good monodispersity and uniform particle size. After the AIE molecules are wrapped by DSPE-PEG₂₀₀₀, the influence of the external environment on them is isolated, and the fluorescence stability is greatly improved, with a lasting stability fluorescence effect.
This series of nanoparticles are near-infrared fluorescent nanoparticles, suitable for in vivo imaging of small animals, and have the characteristics of strong tissue penetration, good water solubility, and low biological toxicity. At the same time, we can provide microspheres with different particle sizes and functional groups, which can meet the diverse needs of customers.
Product Specifications and Parameters
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Product Imaging Steps
The steps are as follows:
Experimental Preparation: Prepare 5 - week - old male Balb/c nude mice, and inject the tumor cell line (1×10⁶/0.1ml) subcutaneously into male Balb/c nude mice or into sites such as the tail vein.
When the tumor volume grows to 60 - 80mm³, perform imaging on the nude mice as a control.
Animal Imaging Experiment: Inject 0.2ml (1mg/ml AIE NPs) of near - infrared fluorescent microspheres into the nude mice via the tail vein, and then perform imaging on the nude mice.
Product Application Scenarios
Example 1: Tumor Imaging
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Example 2: Vascular Imaging
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This protocol is for reference only. Researchers should optimize the specific experimental conditions according to their own projects.
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