N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG , making it a promising candidate for cardiovascular disease research . Additionally, N-Acetyl-D-mannosamine can activate hypocretin ( HCRT ) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders.