| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N408436-1ml |
1ml |
现货  |
|
| 英文别名 | Bayotensin | 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Nitrendipine |
| 生化机理 | 硝苯地平（拜唐苹）是一种二氢吡啶类钙通道阻滞剂，IC50 为 95 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 通道阻滞剂 |
| 作用机制 | Ca v1.1的门控抑制剂;Ca v1.2的门控抑制剂;Ca v1.3的门控抑制剂;Ca v1.4的门控抑制剂;K Ca3.1的通道阻断剂 |
| 产品介绍 |
Information Nitrendipine Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 2.115 |
|---|---|
| hba_count | 4 |
| HBD Count | 1 |
| Rotatable Bond | 7 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC)C |
| 分子量 | 360.3699 |
| Reaxy-Rn | 498823 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=498823&ln= |
| DMSO(mg / mL) Max Solubility | 72 |
|---|---|
| DMSO(mM) Max Solubility | 199.79 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 498823 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=498823&ln= |
| Concentration | 9-11（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Xiuling Tang, Huanhuan Zhao, Wei Jiang, Song Zhang, Shun Guo, Xiaobo Gao, Peng Yang, Lei Shi, Linna Liu. (2018) Pharmacokinetics and pharmacodynamics of citrus peel extract in lipopolysaccharide-induced acute lung injury combined with Pinelliae Rhizoma Praeparatum. Food & Function, 9 (11): (5880-5890). [PMID:30374490] [10.1039/C8FO01337C] |
| 2. Huilin Ma, Yunmei Li, Huan Shi, Biaobiao Wang, He Tian, Xifan Mei, Chao Wu. (2025) Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (139114). [PMID:39755317] [10.1016/j.ijbiomac.2024.139114] |
| 3. Yunmei Li, Huilin Ma, Huan Shi, Biaobiao Wang, Desheng Li, He Tian, Xifan Mei, Chao Wu. (2025) Dextran sulfate-coated curcumin nanocrystals for the treatment of DSS-induced ulcerative colitis in mice. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 674 (125428). [PMID:40043963] [10.1016/j.ijpharm.2025.125428] |
| 1. Xiuling Tang, Huanhuan Zhao, Wei Jiang, Song Zhang, Shun Guo, Xiaobo Gao, Peng Yang, Lei Shi, Linna Liu. (2018) Pharmacokinetics and pharmacodynamics of citrus peel extract in lipopolysaccharide-induced acute lung injury combined with Pinelliae Rhizoma Praeparatum. Food & Function, 9 (11): (5880-5890). [PMID:30374490] [10.1039/C8FO01337C] |
| 2. Huilin Ma, Yunmei Li, Huan Shi, Biaobiao Wang, He Tian, Xifan Mei, Chao Wu. (2025) Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (139114). [PMID:39755317] [10.1016/j.ijbiomac.2024.139114] |
| 3. Yunmei Li, Huilin Ma, Huan Shi, Biaobiao Wang, Desheng Li, He Tian, Xifan Mei, Chao Wu. (2025) Dextran sulfate-coated curcumin nanocrystals for the treatment of DSS-induced ulcerative colitis in mice. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 674 (125428). [PMID:40043963] [10.1016/j.ijpharm.2025.125428] |
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