7-Cl-O-Nec1, 受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂

RIP 激酶抑制剂

Moligand™

10mM in DMSO

CAS编号: 852391-15-2(DMSO)
分子式: C₁₃H₁₂ClN₃O₂
分子量: 277.71

有货

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
N409256-1ml	1ml	现货

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Compound libraries (12332)

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基本描述

英文别名	7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S \| 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl- \| 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione \| Nec-1s \| Necrostatin 2 racemate \| Necrostatin 1s
规格或纯度	Moligand™, 10mM in DMSO
英文名称	7-Cl-O-Nec1
生化机理	Necrostatin 2 消旋体（Nec-1s，7-Cl-O-Nec1，Necrostatin-1 稳定型，Necrostatin 1S）是 Necrostatin-1 的稳定变体。它是一种特异性更强的 RIPK1 抑制剂，缺乏 IDO 靶向效应，对 RIPK1 的选择性是 485 种人类激酶中任何其他激酶的 1000 倍以上。
储存温度	避光,-80℃储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂
产品介绍	Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S)是Necrostatin-1的一种稳态变体（stable variant）,它是一种更为特异的RIPK1抑制剂，没有靶向IDO的效果，对RIPK1的选择性比对其他485种人源激酶高1000倍以上。 Information Necrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selecti In vitro Nec-1s is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity. In vivo Nec-1s is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. Nec-1s possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Safety profile of Nec-1s is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity. Cell Data cell lines：Cell lines: Concentrations： Incubation Time： Powder Purity:≥98%

产品属性

ALogP	2.043
hba_count	2
HBD Count	2
Rotatable Bond	2

关联靶点（人）

RIPK1 Tchem 受体相互作用丝氨酸/苏氨酸蛋白激酶 1(Receptor-interacting serine/threonine-protein kinase 1) (1 活性数据)

点击查看靶蛋白信息： RIPK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

分子类型	小分子
Canonical SMILES	CN1C(=O)NC(CC2=C[NH]C3=C(Cl)C=CC=C23)C1=O
分子量	277.71
Reaxy-Rn	10175735
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10175735&ln=