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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
1,4-萘醌
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N421176-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 1,4-萘醌 | α-萘醌 |
|---|---|
| 英文别名 | N0040 | NCGC00357275-01 | 1,4-NAPHTHOQUINONE [MI] | AI3-24292 | EINECS 204-977-6 | HSDB 2037 | NCGC00164067-01 | STL146359 | naphthalene-1,4-dione | MFCD00001676 | AC-34538 | DTXSID5040704 | naphthalene-1 | Z104494806 | p-Naphthoquinone | 1,4-Naphthylquin |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | 1,4-Naphthoquinone |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
易溶于热醇、醚、苯、氯仿和二硫化碳；溶于碱溶液呈红棕色；难溶于冷水；微溶于石油醚。能随水蒸气挥发，有苯醌气味。加热至100℃即可升华。 1,4-Naphthoquinone was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities. It was also used to inhibit the acetyltransferase activity. |
关联靶点（人）
IDO1
Tchem
吲哚胺2,3-双加氧酶1(Indoleamine 2,3-dioxygenase 1)
(3 活性数据)
TOP1
Tclin
DNA topoisomerase I
(7553 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TOP2A
Tclin
DNA topoisomerase II alpha
(6317 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
THRB
Tclin
Thyroid hormone receptor beta-1
(7926 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CASP3
Tchem
Caspase-3
(3632 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CDC25A
Tchem
Dual specificity phosphatase Cdc25A
(619 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AHR
Tclin
Aryl hydrocarbon receptor
(1071 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HMOX2
Tchem
Heme oxygenase 2
(250 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HMOX1
Tchem
Heme oxygenase 1
(32 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MAP2K1
Tclin
Dual specificity mitogen-activated protein kinase kinase 1
(4127 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CDC25C
Tchem
Dual specificity phosphatase Cdc25C
(295 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PRKACA
Tchem
cAMP-dependent protein kinase alpha-catalytic subunit
(3475 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
AKT1
Tchem
Serine/threonine-protein kinase AKT
(9192 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PIN1
Tchem
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(36611 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
DU-145
(51482 活性数据)
HT-29
(80576 活性数据)
MCF7
(126967 活性数据)
MG-63
(795 活性数据)
Raji
(5516 活性数据)
SK-MEL-28
(48833 活性数据)
SK-OV-3
(52876 活性数据)
A549
(127892 活性数据)
HCT-116
(91556 活性数据)
HepG2
(196354 活性数据)
A2780
(11979 活性数据)
MDA-MB-231
(73002 活性数据)
IDO1
Tchem
Indoleamine 2,3-dioxygenase
(6650 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT1
Tchem
Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
(407 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
EHMT2
Tchem
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
(93046 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SNCA
Tchem
Alpha-synuclein
(10960 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PHGDH
Tchem
D-3-phosphoglycerate dehydrogenase
(883 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
关联靶点（其它种属）
Papain (844 活性数据)
Cdc25b
Dual specificity phosphatase Cdc25B (32 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
protease
Human rhinovirus A protease (1343 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Carbonic anhydrase (69 活性数据)
Pseudomonas aeruginosa (123386 活性数据)
Enterobacter cloacae (7976 活性数据)
Klebsiella pneumoniae (43867 活性数据)
Proteus vulgaris (5823 活性数据)
Staphylococcus aureus (210822 活性数据)
Escherichia coli (133304 活性数据)
Mycobacterium tuberculosis (203094 活性数据)
Enterococcus faecalis (29875 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
P388 (20296 活性数据)
Vero (26788 活性数据)
HT-22 (3261 活性数据)
LLTC cell line (101 活性数据)
Urease (750 活性数据)
Dusp6
Dual specificity protein phosphatase 6 (459 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
botA
Botulinum neurotoxin type A (1303 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Dusp1
Dual specificity protein phosphatase 1 (15 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
mtcA1
Uncharacterized protein Rv1284/MT1322 (182 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ced-3
Cell death protein 3 (4 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
CELA2A
Pancreatic elastase (395 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
groL
GroEL/GroES (1042 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 204-977-6 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | naphthalene-1,4-dione |
| INCHI | InChI=1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H |
| InChi Key | FRASJONUBLZVQX-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=O)C=CC(=O)C2=C1 |
| Isomeric SMILES | C1=CC=C2C(=O)C=CC(=O)C2=C1 |
| WGK Germany | 3 |
| RTECS | QL7175000 |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 158.15 |
| Beilstein号 | 878524 |
| Reaxy-Rn | 878524 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=878524&ln= |
化学和物理性质
| 敏感性 | 对光线敏感 |
|---|---|
| 闪点(℉) | 285.8 °F |
| 闪点(℃) | 141°C |
| 熔点 | 120-124°C |
| 分子量 | 158.150 g/mol |
| XLogP3 | 1.700 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 158.037 Da |
| 单同位素质量Monoisotopic Mass | 158.037 Da |
| 拓扑极表面积Topological Polar Surface Area | 34.100 Ų |
| 重原子数Heavy Atom Count | 12 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 227.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS06, GHS09, GHS05 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H314: 造成严重的皮肤灼伤和眼睛损伤 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H330: 吸入致命 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P363: 再次使用之前，请清洗受污染的衣物。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P391: 收集溢出物 P330: 漱口 P320: 迫切需要特殊治疗（请参阅此标签上的...）。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P302+P361+P354: 如果接触皮肤：立即脱掉所有被污染的衣服。立即用水冲洗几分钟。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| WGK Germany | 3 |
| RTECS | QL7175000 |
| Reaxy-Rn | 878524 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=878524&ln= |
| Class | 6.1 |
| 个人防护装备 | Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges |
技术规格说明书
| Concentration | 9-11（mmol/L） |
|---|---|
| Infrared spectrum | Conforms to structure |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu. (2024) A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode. BIOSENSORS & BIOELECTRONICS, 246 (28): (115845). [PMID:38008057] [10.1016/j.bios.2023.115845] |
| 2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
| 3. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li. (2023) Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms. Separations, 10 (6): (335). [10.3390/separations10060335] |
| 4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang. (2023) Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl. ANALYTICAL CHEMISTRY, 95 (8): (4015–4023). [PMID:36802553] [10.1021/acs.analchem.2c04373] |
| 5. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong. (2019) Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (27): (7105-7113). [PMID:31515585] [10.1007/s00216-019-02092-7] |
| 6. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han. (2019) Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (17): (10053–10061). [PMID:31389239] [10.1021/acs.est.9b02327] |
| 7. Chuantao Hou, Qiaolin Lang, Aihua Liu. (2016) Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation. ELECTROCHIMICA ACTA, 211 (663). [10.1016/j.electacta.2016.06.078] |
| 8. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu. (2015) Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes. JOURNAL OF APPLIED POLYMER SCIENCE, 132 (36): [10.1002/app.42498] |
| 9. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
| 10. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong. (2014) A rapid method for determination of acid value in transformer oil by PPy modified electrode. Journal of Central South University, 21 (6): (2202-2207). [10.1007/s11771-014-2171-5] |
参考文献
| 1. Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Yi-Heng P. Job Zhang, Zhiguang Zhu. (2024) A wearable and flexible lactic-acid/O2 biofuel cell with an enhanced air-breathing biocathode. BIOSENSORS & BIOELECTRONICS, 246 (28): (115845). [PMID:38008057] [10.1016/j.bios.2023.115845] |
| 2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
| 3. Nian Wang, Die Zhou, Huaying Liu, Yina Tu, Yanqiong Ma, Yingjie Li. (2023) Triplet-Excited Dissolved Organic Matter Efficiently Promoted Atmospheric Sulfate Production: Kinetics and Mechanisms. Separations, 10 (6): (335). [10.3390/separations10060335] |
| 4. Yitao Lv, Yi Zhang, Yunyin Yang, Jingyan Li, Jiacheng Wang, Xilin Xiao, Min Zhang. (2023) Strategy of In Situ Electrochemical Regulation for Highly Enhanced Nonenzymatic Sensing of Carbaryl. ANALYTICAL CHEMISTRY, 95 (8): (4015–4023). [PMID:36802553] [10.1021/acs.analchem.2c04373] |
| 5. Zhang Nana, Li Jian, Zhang Panpan, Yang Xiaodi, Sun Chong. (2019) Novel nanoarchitecture of arginine-glycine-aspartate conjugated gold nanoparticles: a sensitive and selective platform for detecting arachidonic acid. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411 (27): (7105-7113). [PMID:31515585] [10.1007/s00216-019-02092-7] |
| 6. Qingcai Chen, Haoyao Sun, Mamin Wang, Yuqin Wang, Lixin Zhang, Yuemei Han. (2019) Environmentally Persistent Free Radical (EPFR) Formation by Visible-Light Illumination of the Organic Matter in Atmospheric Particles. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53 (17): (10053–10061). [PMID:31389239] [10.1021/acs.est.9b02327] |
| 7. Chuantao Hou, Qiaolin Lang, Aihua Liu. (2016) Tailoring 1,4-naphthoquinone with electron-withdrawing group: toward developing redox polymer and FAD-GDH based hydrogel bioanode for efficient electrocatalytic glucose oxidation. ELECTROCHIMICA ACTA, 211 (663). [10.1016/j.electacta.2016.06.078] |
| 8. Hengnong Li, Chongbo Liu, Bing Dai, Xinghua Tang, Z. John Zhang, Zhiqiang Xiong, Xiaoming Liu. (2015) Synthesis, conductivity, and electromagnetic wave absorption properties of chiral poly Schiff bases and their silver complexes. JOURNAL OF APPLIED POLYMER SCIENCE, 132 (36): [10.1002/app.42498] |
| 9. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
| 10. Xiong Ying, He De-liang, Feng Yong, Zhou Zhou, Chang Xin-yuan, Liu Fu-rong. (2014) A rapid method for determination of acid value in transformer oil by PPy modified electrode. Journal of Central South University, 21 (6): (2202-2207). [10.1007/s11771-014-2171-5] |