计算溶液所需的质量、体积或浓度。
概述
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 . SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM .
In Vitro
N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK)
规格
别名
N-哌啶盐酸伊布替尼
规格或纯度
10mM in DMSO
英文名称
N-piperidine Ibrutinib hydrochloride
生化机理
N-piperidine Ibrutinib 盐酸盐（化合物 1）是一种可逆的 Ibrutinib 衍生物。N-piperidine Ibrutinib 盐酸盐是一种强效的 BTK 抑制剂，对 WT BTK 和 C481S BTK 的 IC 50 s 分别为 51.0 和 30.7 nM。N-piperidine Ibrutinib hy
储存条件
避光,干燥,-80℃储存
运输条件
特低温运输
名称和识别符
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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