计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research.
In Vitro
Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (150-200 g)Dosage: 60 mg/kg Administration: Intraperitoneal injection; once Result: Increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment.
规格
别名
尼普拉嗪
规格或纯度
10mM in DMSO
英文名称
Niaprazine
生化机理
尼普拉嗪是一种组胺 H1 受体拮抗剂。尼普拉嗪具有抗组胺和抗对羟色胺活性，可用于睡眠障碍研究。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
拮抗剂
名称和识别符
EC号
248-431-5, 620-536-4
分子类型
小分子
Isomeric SMILES
CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3
PubChem CID
MeSH Entry Terms
niaprazine;niaprazine trihydrochloride;Nopron
分子量
356.4
技术文档
高级数据
安全和危险性（GHS）
信号词
警告
危险声明
H302: 吞食有害
H315: 引起皮肤刺激
H319: 引起严重眼睛刺激
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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