OICR41114 ( PROTAC 4) is a WDR5 -targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC 50 and D max values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner. OICR41114 is composed of target protein ligand (red part) Dimethyl-F-OICR-9429-COOH , E3 ligase ligand (blue part) OICR-8268-acrylic acid and PROTAC linker (black part) Amino-PEG9-amine. The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid -amino-PEG9-amine.