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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 7 篇同行评审文献引用。
概述
Information
Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.
In vitro
Octopamine is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied, and modulates almost every physiological process. Octopamine acts as neurohormone including desensitization of sensory inputs, influence on learning and memory, or regulation of the mood of the animal in the central nervous system. Octopamine is the only neuroactive non-peptide transmitter whose physiological role is restricted to invertebrates, and all octopamine receptors belong to the family of G-protein coupled receptors.
In vivo
Octopamine (10 mg/mL) is necessary for the acquisition of sugar memory in Drosophila. Octopamine treatment increases responsiveness to brood pheromone and decreased responsiveness to social inhibition. Octopamine acts as an important source of variation in response thresholds and as a modulator of pheromonal communication in insect societies. Octopamine (10 μM) injected into the mushroom body (MB) calyces or the antennal lobe but not the lateral protocerebral lobe produces a lasting, pairing-specific enhancement of extension of the proboscis. Octopamine (10 μM) injected into the MB calyces results in an additional pairing-specific effect, because it does not lead to an acquisition but a consolidation after conditioning. Octopamine treatment significantly elevates levels of octopamine in the brain and caused a significant dose-dependent increase in the number of new foragers. Octopamine treatment is effective only when given to bees old enough to forage, i.e., older than 4 days of age. Octopamine influences division of labor in honey bee colonies.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
4-(2-amino-1-hydroxyethyl)phenol hydrochloride
规格或纯度
Moligand™, 10mM in DMSO
英文名称
(+,-)-Octopamine HCl
生化机理
奥克多巴胺（OA）是一种生物单胺类物质，在结构上与去甲肾上腺素有关，是无脊椎动物的一种神经激素、神经调节剂和神经递质。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
作用机制
Agonist of TA 1 receptor
名称和识别符
PubChem SID
EC号
212-216-4
分子类型
小分子
Isomeric SMILES
C1=CC(=CC=C1C(CN)O)O.Cl
分子量
189.64
Beilstein号
3915414
Reaxy-Rn
3915414
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3915414&ln=
技术文档
高级数据
关联靶点（人）
TAAR1
Tclin
微量胺相关受体 1(Trace amine-associated receptor 1)
(1 活性数据)
化学和物理性质
分子量
189.640 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count
4
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
2
精确质量Exact Mass
189.056 Da
单同位素质量Monoisotopic Mass
189.056 Da
拓扑极表面积Topological Polar Surface Area
66.500 Ų
重原子数Heavy Atom Count
12
形式电荷Formal Charge
0
复杂度Complexity
111.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
1
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
2
安全和危险性（GHS）
信号词
警告
危险声明
H302: 吞食有害
WGK Germany
3
个人防护装备
dust mask type N95 (US),Eyeshields,Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
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