| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O426476-1ml |
1ml |
现货  |
|
| 英文别名 | 9GL | HMS3651O11 | EN300-60161 | 5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide | AC-32888 | AS-56123 | Org27569 | ORG-27569 | 7YW2S3Z2CB | 6-(Trifluoromethyl)-1,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | 5-chloro-3-ethyl-N-[ |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Org 27569 |
| 生化机理 | Org 27569 是一种 CB1 受体异构调节剂。可增加与 CB1 激动剂的结合。抑制体外 CB1 受体拮抗剂的效力。强效 CB1 受体异构调节剂（pEC 50 = 8.24）。显著增加 CB1 激动剂 [ 3 H]CP 55,940 的结合力（pK b = 5.67），降低 CB1 反向激动剂 [ 3 H]SR 141716A 的结合力（pK b = 5.95）。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 变构调节剂 |
| 作用机制 | CB 1 受体的异构调节剂 |
| 产品介绍 |
Org 27569是cannabinoid CB1 receptor变构调节剂，通过增强激动剂亲和力而诱导CB1受体状态改变，且降低逆向激动剂的亲和力。 Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity. |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 278-169-7 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 5-chloro-3-ethyl-N-[2-(4-piperidin-1-ylphenyl)ethyl]-1H-indole-2-carboxamide |
| INCHI | InChI=1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29) |
| InChi Key | AHFZDNYNXFMRFQ-UHFFFAOYSA-N |
| Canonical SMILES | CCC1=C(NC2=C1C=C(C=C2)Cl)C(=O)NCCC3=CC=C(C=C3)N4CCCCC4 |
| Isomeric SMILES | CCC1=C(NC2=C1C=C(C=C2)Cl)C(=O)NCCC3=CC=C(C=C3)N4CCCCC4 |
| 分子量 | 409.95 |
| Reaxy-Rn | 10210988 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10210988&ln= |
| 敏感性 | 对湿度敏感 |
|---|---|
| 分子量 | 409.900 g/mol |
| XLogP3 | 6.000 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 409.192 Da |
| 单同位素质量Monoisotopic Mass | 409.192 Da |
| 拓扑极表面积Topological Polar Surface Area | 48.100 Ų |
| 重原子数Heavy Atom Count | 29 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 530.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Reaxy-Rn | 10210988 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10210988&ln= |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
首页
400-620-6333
