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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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概述
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research.
In Vitro
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues . 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:PPARγ NF-κB
规格
别名
4-O-甲基和厚朴酚
规格或纯度
10mM in DMSO
英文名称
4-O-Methyl honokiol
生化机理
4-O-Methyl honokiol 是一种从厚朴中分离出来的天然新木犀草素，可作为 PPARγ 激动剂，抑制 NF-κB 活性，用于癌症和炎症研究。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
名称和识别符
分子类型
小分子
Isomeric SMILES
COC1=C(C=C(C=C1)C2=C(C=CC(=C2)CC=C)O)CC=C
关联CAS
PubChem CID
NSC Number
293101
MeSH Entry Terms
4-O-methylhonokiol
分子量
280.36
高级数据
关联靶点（人）
CNR2
Tchem
大麻素受体 2(Cannabinoid receptor 2)
(1 活性数据)
安全和危险性（GHS）
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 68592-15-4，分子式为 C19H20O2，分子量为 280.36 g/mol。
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