PBE-AMF is a prodrug that activates H 2 O 2 with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis , and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells ( IC 50 =6.4 μM) while sparing non-cancerous MCF-10A cells.