Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan- Trk and their drug-resistant mutants with IC 50 values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA , TrkB , TrkC , TrkA G595R , TrkA G667C , TrkA G667S , TrkA F589L and TrkC G623R , respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis.