PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 PROTAC degrader with IC 50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research (Pink: Mivebresib ; Black: linker, Azido-PEG1-CH2CO2H ; Blue: Lenalidomide ).