Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV ( Plm IV ) inhibitor with IC 50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites.