PMEG-DP disodium is a potent DNA polymerase inhibitor ( IC 50 =2.5 μM), especially for DNA polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus ( HPV ) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases.