PROTAC PARP1 degrader-2 (Compound 72) is a PROTAC degrader for PARP with a DC 50 <10 nM in MDA-MB-231 cell. PROTAC PARP1 degrader-2 inhibits the cell viability of MDA-MB-436 with an IC 50 <100 nM. (Blue: ligand for target protein ; Pink: ligand for E3 ligase )