PP487 is a dual inhibitor of tyrosine kinase/PI(3)Ks with IC 50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK , mTOR , Hck , Src , EGFR , EphB4 , and PDGFR , respectively. PP487 can be used for cancer research.