PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 ( PRMT5 ) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis , enhance invasion and metastasis, and affect immune escape.