PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC 50 <100 nM in A549 and in MV411, degrades SMARCA4 with DC 50 <100 nM in MV411(Pink: Ligand for target protein ; Black: Linker ; Blue: Ligand for E3 ligase (S,R,S)-AHPC )