PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC 50 <100 nM, degrades SMARCA4 in MV411 with DC 50 <100 nM. (Pink: Ligand for Target Protein ; Black: Linker ; Blue: Ligand for E3 Ligase )