PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC 50 of <100 and 100-500 nM. (Pink: Ligand for target protein ; Black: Linker ; Blue: Ligand for E3 ligase (S,R,S)-AHPC )