PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC , which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 ; Black: linker ; Blue: E3 ligase ligand Thalidomide 4-fluoride )