PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC 50 <100 nM, degrades SMARCA4 in MV411 with DC 50 of 100-500 nM. (Pink: Ligand for Target Protein ; Black: Linker ; Blue: Ligand for E3 Ligase )