PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2 in A549 and in MV411 with DC 50 <100 nM, degrades SMARCA4 in MV411 with DC 50 <100 nM. (Pink: ligand for target protein ; Black: linker ; Blue: ligand for E3 ligase ).