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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
PROTAC BRD4 Degrader-27 (compound 6b) is a PROTAC that selectively targets BRD4 (rather than BRD2/BRD3) and can also inhibit the expression of KLF5 transcription factor and exert anti-cancer activity. PROTAC BRD4 Degrader-27 is composed of E3 ubiquitinase ligand Thalidomide-4-OH (red part), PROTAC Linker γ-Aminobutyric acid (black part) and PROTAC target protein ligand PROTAC BRD4 ligand-3 (blue part), of which the active control of the target protein ligand is Mivebresib , and the conjugate of E3 ubiquitin ligase ligand + Linker is Pomalidomide 4'-alkylC3-acid.