PROTAC METTL3 degrader 1 (Compound KH12) is a VHL-based PROTAC METTL3 degrader (DC 50 : 220 nM in MOLM-13 cells). PROTAC METTL3 degrader 1 inhibits METTL3/14 complex with an IC 50 value of 341 nM. PROTAC METTL3 degrader 1 has anti-proliferative activities against AML cells.Black: Linker ; Red: METTL3 ligand ; Blue: VHL ligand.