PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader, with a DC 50 of 10 nM. PROTAC JNK1-targeted-1 (PA2) decreases the level of Fibronectin protein. PROTAC JNK1-targeted-1 can be used for the research of pulmonary fibrosis. (Pink: JNK1 inhibitor ; Black: linker ; Blue: CRBN Ligand )