PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with a DC 50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC 50 value of 0.12μM against A2780 cells. (Structure Note: PINK, NAMPT activator ; Blue,VHL ligand ; Black, linker).