PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain ( TEAD ). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC 50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC 50 of 0.21 μM, and regulates expressions of yes associated protein ( YAP ) target genes. (Pink: TEAD ligand ; Black: linker ; Blue: E3 ligase ligand )