PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs , which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways, IC 50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor ; Blue, E3 ; Black, linker ).