PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 ( GSPT1 ) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC 50 of 9.2 nM. (Pink: ligand for target protein ; Black: linker ; Blue: ligand for E3 ligase )