PROTAC HDAC8 Degrader-2 (compound 32a) is a degrader of HDAC8 with a DC 50 of 8.9 nM and HDAC6 with a DC 50 of 14.3 nM. PROTAC HDAC8 Degrader-2 is composed of PROTAC target protein ligand HDAC8 ligand 1 (red part), E3 ligase ligand Thalidomide-4-OH (blue part) and PROTAC Linker 1,5-Diaminopentane (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-NH-C5-NH2.