PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs , with the DC 50 of 45 nM inH3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment.