PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1 , with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (red part), E3 ligase ligand Thalidomide (blue part), and PROTAC linker (black part).