PROTAC ERα Degrader-7 (compound i-320) is a potent estrogen receptor alpha( ERα ) PROTAC degrader with a DC 50 value of 0.000006 µM. PROTAC ERα Degrader-7 comprises a cereblon-binding moiety LBM linked to a ligand ERBM that binds ERα and comprises a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring.