PROTAC AR Degrader-7 (compound 99) is a PROTAC targeting androgen receptor with an IC 50 value of 3 nM. PROTAC AR Degrader-7 is composed of PROTAC target protein ligand AR ligand-32 (red part), E3 ligase ligand E3 ligase Ligand 44 (blue part) and PROTAC Linker N-Boc-piperazine (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 145.