PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor , that degrades AR in human hair follicle papilla cells (HDPCs) with a DC 50 of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-β1 and β-catenin , exhibits hair regenerating efficacy in mouse models. (Pink: ligand for target protein AR ligand-38 ; Black: linker; Blue: ligand for E3 ligase Cereblon )