PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase ( Pin1 ) with an IC 50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1 , induces conformational changes in Pin1 , reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research.