肿瘤的精确诊断与高效治疗一直是医学界的难题和研究热点，设计制备兼具诊断、监控和治疗等功能为一体，且具有良好生物安全性的纳米诊疗剂是实现肿瘤精准治疗的材料基础。普鲁士蓝作为一种古老的染料，是一种美国食品和药物管理局批准作为临床上治疗铊等放射性元素中毒的解毒剂。普鲁士蓝纳米颗粒 (PBNPs) 化学结构稳定，具有优良的物理、化学、光学以及磁性等性质。同时该材料因其良好的光热转换性能，近年来在药物输送、肿瘤光声成像和光热治疗受到研究者的极大关注。
阿拉丁提供高质量的PVP修饰普鲁士蓝纳米颗粒，低毒、安全环保无污染，分散性、稳定性佳。可用于抗炎、抗氧化、肿瘤光热疗、核磁共振成像、铊解毒剂等。
产品名称
| PVP修饰普鲁士蓝纳米颗粒
|
水动力尺寸
| ＜100 nm
|
表面修饰分子
| PVP
|
溶剂
| 超纯水
|
浓度
| 0.25 mg/mL |
图1：PVP修饰普鲁士蓝纳米颗粒的合成机理图
产品参数
1. 电镜图
透射电镜尺寸约为 50 nm。
图2：PVP修饰普鲁士蓝纳米颗粒的 TEM 电镜图
2. 紫外- 可见光谱吸收
PVP修饰普鲁士蓝纳米颗粒在 700 nm 左右有特征吸收。
使用效果
PVP修饰鲁士蓝纳米颗粒用于抗氧化实验
实验结果验证了 PBNPs 可以保护细胞免受紫外（UVA）、二烯丙基三硫（DATS）、脂多糖（LPS）、佛波酯（PMA）、高糖等培养环境引起的自由基损伤，并且可以保护神经海马细胞在 OGD 复氧过程中的损伤，提示 PBNPs 是一种潜在的脑部缺血再灌注损伤保护剂。使用 LPS 建立的动物肝炎模型验证了 PBNPs 在小鼠体内累积在肝和脾，并可以有效地保护小鼠肝脏免受 LPS 诱导产生肝部炎症。
Precision diagnosis and efficient treatment of tumors have long been challenges and research focal points in the medical field. The design and preparation of nanotheranostic agents that integrate diagnosis, monitoring, and treatment functions while maintaining good biosafety constitute the material foundation for achieving precision tumor therapy. Prussian blue, as an ancient dye, is a detoxifying agent approved by the U.S. Food and Drug Administration for clinical treatment of poisoning from radioactive elements such as thallium. Prussian blue nanoparticles (PBNPs) possess a stable chemical structure and exhibit excellent physical, chemical, optical, and magnetic properties. Additionally, due to their favorable photothermal conversion performance, they have garnered significant research attention in recent years for applications in drug delivery, tumor photoacoustic imaging, and photothermal therapy.
Aladdin offers high-quality PVP-modified Prussian blue nanoparticles, which are low-toxicity, safe, environmentally friendly, and feature excellent dispersibility and stability. They can be used in anti-inflammatory, antioxidant, tumor photothermal therapy, magnetic resonance imaging, and thallium detoxification applications.
Product Name
| PVP-Modified Prussian Blue Nanoparticles
|
Hydrodynamic Size
| ＜100 nm
|
Surface Modification Molecule
| PVP
|
Solvent
| Ultrapure Water
|
Concentration
| 0.25 mg/mL |
Figure 1: Schematic Diagram of the Synthesis Mechanism of PVP-Modified Prussian Blue Nanoparticles
Product Parameters
1. Electron Microscopy Image
The transmission electron microscopy (TEM) size is approximately 50 nm.
Figure 2: TEM Image of PVP-Modified Prussian Blue Nanoparticles
2. UV-Vis Absorption Spectrum
PVP-modified Prussian blue nanoparticles exhibit a characteristic absorption peak at around 700 nm.
Application Performance
Use of PVP-Modified Prussian Blue Nanoparticles in Antioxidant Experiments
Experimental results have demonstrated that PBNPs can protect cells from free radical damage induced by culture conditions such as UVA radiation, diallyl trisulfide (DATS), lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), and high glucose. Additionally, they can protect hippocampal neurons from damage during oxygen-glucose deprivation (OGD) and reoxygenation, suggesting that PBNPs are a potential protective agent against cerebral ischemia-reperfusion injury. Using an animal model of hepatitis induced by LPS, it was verified that PBNPs accumulate in the liver and spleen of mice and effectively protect the mouse liver from LPS-induced inflammation.
ZJ26F0737655
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