BioReagent 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
It has been known for many years [Mosseson MW & Finlayson]S.] Lab Clin Med 62:663, 1963] that human fibrinogen can be sufractionated chromatographically into two peaks called Peak ‘1’ and Peak ‘2’ Fibrinogen respectively. These fibrinogens differ from one another with respect to their gamma chain composition. Peak ‘1’ fibrinogen accounts for 85% of the total plasma fibrinogen and has two gamma-A chains, whereas Peak ‘2’ fibrinogen accounts for the remaining 15% and contains one gamma-A chain and one gamma chain per molecule. Peak ‘1’ fibrinogen contains mostly intact A-alpha subunit chains, is free of plasminogen, factor XIII, fibronectin, and other non-fibrinogen protein contaminants. Peak 1′ fibrinogen molecules each contain two copies of the platelet-binding gamma-A chain C-terminal sequence and are ideal substrates for factor XIII assay. Peak ‘2’ fibrinogen contains measurable amounts of factor XIII activity because the factor XIII B subunits bind to gamma chains and bring catalytic A subunits along with them. Thus Peak ‘2’ fibrinogen serves as a ‘carrier’ for factor XIII in blood. The gamma chain lacks the platelet recognition sequence but, like all gamma chains, become crosslinked to dimers by factor XIIIa. Molecular Weights = 340,000 daltons Extinction Coefficients (1%) = 15.1 Clottability = > 95% Peak 1 fibrinogen accounts for 85% of the total plasma fibrinogen and has two gammaA chains. The protein contains mostly intact A alpha subunit chains, is free of plasminogen, factor XIII, fibronectin and other nonfibrinogen protein contaminants. Peak 1 molecules each contain two copies of the platelet-binding gammaA chain C-terminal sequence and are ideal substrates for factor XIII assay. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD. Fibrinogen MUST be thawed in a 37℃ water bath. Once thawed, do not chill. Remaining protein may be aliquoted into single use size and frozen at -80℃.
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