Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is sμggested that piperine exerts its chemopreventive effect by aμgmenting antioxidant defense system and modulating lipid peroxidation.A black pepper extract TRPV1 activator.

Information

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
In vitro

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor.

In vivo

LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

规格

英文别名

1-Piperoylpiperidine | 2,4-Pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2E,4E)-

规格或纯度

Moligand™, 10mM in DMSO

英文名称

Piperine

生化机理

胡椒碱（1-哌酰基哌啶）是一种生物碱，是黑胡椒和长辣椒辛辣味的来源，也被用于某些传统医药和杀虫剂中。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

EC号

202-348-0

分子类型

小分子

Isomeric SMILES

C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3

分子量

285.34

Beilstein号

90741

Reaxy-Rn

90739

Reaxys-RN link address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=90739&ln=

高级数据

关联靶点（人）

TRPV1 Tclin 瞬时受体电位阳离子通道亚家族V成员1(Transient receptor potential cation channel subfamily V member 1) (1 活性数据)

点击查看靶蛋白信息： TRPV1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

MAOB Tclin 胺氧化酶[含黄素]B(Amine oxidase [flavin-containing] B) (1 活性数据)

点击查看靶蛋白信息： MAOB

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

化学和物理性质

溶解性

Solubility (25°C) In vitro DMSO: 56 mg/mL warmed with 50ºC Water: bath (196.94 mM); Ethanol: 11 mg/mL warmed with 50ºC Water: bath (38.68 mM); Water: Insoluble;

熔点

128-132°C

安全和危险性（GHS）

象形图

GHS06

信号词

危险

危险声明

H301: 吞咽会中毒

预防措施声明

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放