| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P407794-1ml |
1ml |
现货  |
|
| 英文别名 | 1-Piperoylpiperidine | 2,4-Pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2E,4E)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Piperine |
| 生化机理 | 胡椒碱（1-哌酰基哌啶）是一种生物碱，是黑胡椒和长辣椒辛辣味的来源，也被用于某些传统医药和杀虫剂中。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is sμggested that piperine exerts its chemopreventive effect by aμgmenting antioxidant defense system and modulating lipid peroxidation.A black pepper extract TRPV1 activator. Information Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide. Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor. In vivo LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.) cell lines： Concentrations： Incubation Time： Powder Purity:≥98% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | O=C(\C=C\C=C\C1=CC2=C(OCO2)C=C1)N3CCCCC3 |
| 分子量 | 285.34 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 56 mg/mL warmed with 50ºC Water: bath (196.94 mM); Ethanol: 11 mg/mL warmed with 50ºC Water: bath (38.68 mM); Water: Insoluble; |
|---|
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai, Baoxin Zhang. (2023) Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis. BIOORGANIC CHEMISTRY, (106589). [PMID:37320912] [10.1016/j.bioorg.2023.106589] |
| 2. Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. (2023) The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. FOOD CHEMISTRY, 420 (136119). [PMID:37060667] [10.1016/j.foodchem.2023.136119] |
| 3. Ning Jia, Pengfei Guo, Kaiyuan Zhang, Chen Liu, Ruihao Chen, Zhe Liu, Qian Ye, Hongqiang Wang. (2022) Defect Passivation by Natural Piperine Molecule Enabling for Stable Perovskite Solar Cells with Efficiencies over 23%. ACS Sustainable Chemistry & Engineering, 10 (49): (16359–16367). [10.1021/acssuschemeng.2c05527] |
| 4. Ligang Yu, Yong Li, Yukun Yang, Caixia Guo, Meiping Li. (2022) Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4646-4655). [10.1111/ijfs.15804] |
| 5. Song Lingyu, Wang Yan, Zhen Yunhuan, Li Dengke, He Xidong, Yang Hong, Zhang Huayang, Liu Qi. (2020) Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition. BIOTECHNOLOGY LETTERS, 42 (10): (2049-2058). [PMID:32500474] [10.1007/s10529-020-02923-z] |
| 6. Liu Kai, Liu Huijun, Li Zhendong, Li Wei, Li Liuxing. (2020) In vitro dissolution study on inclusion complex of piperine with ethylenediamine-β-cyclodextrin. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 96 (3): (233-243). [10.1007/s10847-020-00980-5] |
| 7. Hongyan He, Qi Zhang, Jian-Rong Wang, Xuefeng Mei. (2017) Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals. CRYSTENGCOMM, 19 (41): (6154-6163). [10.1039/C7CE01468F] |
| 1. 陈帅. (2020) Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core. Food Hydrocolloids, 1 (103): (105651). [https://doi.org/10.1016/j.foodhyd.2020.105651] |
| 2. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai, Baoxin Zhang. (2023) Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis. BIOORGANIC CHEMISTRY, (106589). [PMID:37320912] [10.1016/j.bioorg.2023.106589] |
| 3. Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. (2023) The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. FOOD CHEMISTRY, 420 (136119). [PMID:37060667] [10.1016/j.foodchem.2023.136119] |
| 4. Ning Jia, Pengfei Guo, Kaiyuan Zhang, Chen Liu, Ruihao Chen, Zhe Liu, Qian Ye, Hongqiang Wang. (2022) Defect Passivation by Natural Piperine Molecule Enabling for Stable Perovskite Solar Cells with Efficiencies over 23%. ACS Sustainable Chemistry & Engineering, 10 (49): (16359–16367). [10.1021/acssuschemeng.2c05527] |
| 5. Ligang Yu, Yong Li, Yukun Yang, Caixia Guo, Meiping Li. (2022) Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4646-4655). [10.1111/ijfs.15804] |
| 6. Song Lingyu, Wang Yan, Zhen Yunhuan, Li Dengke, He Xidong, Yang Hong, Zhang Huayang, Liu Qi. (2020) Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition. BIOTECHNOLOGY LETTERS, 42 (10): (2049-2058). [PMID:32500474] [10.1007/s10529-020-02923-z] |
| 7. Liu Kai, Liu Huijun, Li Zhendong, Li Wei, Li Liuxing. (2020) In vitro dissolution study on inclusion complex of piperine with ethylenediamine-β-cyclodextrin. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 96 (3): (233-243). [10.1007/s10847-020-00980-5] |
| 8. Hongyan He, Qi Zhang, Jian-Rong Wang, Xuefeng Mei. (2017) Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals. CRYSTENGCOMM, 19 (41): (6154-6163). [10.1039/C7CE01468F] |
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