| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P407870-1ml |
1ml |
现货  |
|
| 别名 | 吡格列酮 (AD-4833) |
|---|---|
| 英文别名 | U 72107 | 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Pioglitazone (AD-4833) |
| 生化机理 | 吡格列酮（AD-4833，U 72107）是一种选择性过氧化物酶体增殖激活受体-γ（PPARγ）激动剂，用于治疗糖尿病；是全长 hPPARα 的弱激活剂，但不是全长 hPPARδ。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 过氧化物酶体增殖激活受体-γ 的激动剂；TRPM3 的通道阻断剂 |
| 产品介绍 |
Pioglitazone 是一种选择性过氧化物酶体增殖物激活受体γ激动剂。A PPAR agonist with potential antidiabetic characteristics. Information Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ. Pioglitazone\xa0is\xa0metabolised\xa0mainly by\xa0CYP2C8\xa0and to a lesser extent by\xa0CYP3A4\xa0in\xa0vitro.\xa0 In vivo Pioglitazone\xa0significantly attenuates left\xa0ventricular\xa0(LV) cavity dilatation and dysfunction by echocardiography as well as LV end-diastolic pressure\xa0in mice with extensive anterior myocardial\xa0infarction.\xa0Pioglitazone partially normalizes LV dP/dt(max) and dP/dt(min), indices of LV contractile function, which are significantly reduced in MI mice. Pioglitazone\xa0results in a reduced activation\xa0of microglia, reduced\xa0induction\xa0of\xa0iNOS-positive cells and less glial fibrillary acidic protein positive cells in both striatum and substantia nigra pars compacta of MPTP mouse\xa0model\xa0of\xa0Parkinson\'s\xa0disease. Pioglitazone\xa0almost completely blocks staining of TH-positive neurons for nitrotyrosine, a marker of NO-mediated cell damage.\xa0 Pioglitazone\xa0(approximately 20 mg/kg/day) attenuates the MPTP-induced glial activation and prevents the dopaminergic cell loss in the substantia nigra pars compacta (SNpc) in MPTP mouse\xa0model\xa0of\xa0Parkinson\'s\xa0disease. Pioglitazone results in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and cortex of 10-month-old\xa0APPV717I\xa0transgenic mice.\xa0Pioglitazone treatment\xa0reduces the expression of the proinflammatory enzymes cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS).\xa0Pioglitazone decreases beta-secretase-1 (BACE1) mRNA and protein\xa0levels, and also a 27% reduction in the\xa0levels\xa0of soluble\xa0Abeta1-42\xa0peptide.\xa0 cell lines： Concentrations： Incubation Time： Powder Purity:≥98% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCC1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1 |
| 分子量 | 356.44 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 29 mg/mL (198.43 mM); Water: 29 mg/mL (198.43 mM); Ethanol: 29 mg/mL (198.43 mM); |
|---|
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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