计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Pranoprofen 是一种非甾体抗炎试剂 (NSAID)，用于角膜炎或其他眼科疾病的研究。Pranoprofen 抑制 COX1/2 酶，从而阻断花生四烯酸转化为二十烷醇，减少前列腺素的合成。
Information
Pranoprofen Pranoprofen (Pyranoprofen) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
In vitro
Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. Pranoprofen alone induces eIF2alpha phosphorylation, which is further increased by ER stress. Pranoprofen inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells. Pranoprofen (0.0625 to 1.0\u2009g/L) has poignant cytotoxicity to human corneal endothelial (HCE) cells, and the extent of its cytotoxicity is dose- and time-dependent. Pranoprofen induces plasma membrane permeability elevation, DNA fragmentation, and apoptotic body formation, proving its apoptosis inducing effect on HCE cells. Pranoprofen above 0.0625\u2009g/L has poignant cytotoxicity on HCE cells in vitro by inducing cell apoptosis, and should be carefully employed in eye clinic.
In vivo
Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively. Pranoprofen is excreted in the urine exclusively in the form of pranoprofen glucuronide in rabbit. Pranoprofen, especially the R(-)-isomer, is significantly distributed in the kidney of rabbit. Pranoprofen has a preference for glucosidation rather than glucuronidation in mice at low doses in spite of having a higher capacity of glucuronidation.
Cell Data
cell lines：KIM-2, HC11, and ES
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
Pyranoprofen | α-methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
规格或纯度
10mM in DMSO
英文名称
Pranoprofen
生化机理
普拉洛芬（吡诺布洛芬）是一种非甾体类 COX 抑制剂，可作为眼科抗炎药物使用。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
682-035-7
分子类型
小分子
Isomeric SMILES
CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O
分子量
255.27
Reaxy-Rn
889798
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=889798&ln=
技术文档
高级数据
化学和物理性质
熔点
181-183°C
安全和危险性（GHS）
信号词
危险
危险声明
H301: 吞咽会中毒
RTECS
DJ3100950
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
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