| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P408671-1ml |
1ml |
现货  |
|
| 英文别名 | UCB 6215 | 1-Pyrrolidineacetamide, 2-oxo- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Piracetam |
| 生化机理 | 吡拉西坦（UCB 6215）是神经递质γ-氨基丁酸（GABA）的环状衍生物，可用于治疗多种认知障碍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 变构调节剂 |
| 作用机制 | GluA1 的受体调节剂;GluA2 的受体调节剂;GluA3 的受体调节剂;GluA4 的受体调节剂 |
| 产品介绍 |
用途： 吡拉西坦用于研究6种吡拉西坦共晶体的晶体结构和理化性质。它还用于研究其体外抗氧化特性。 Information Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders. Piracetam is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960). Piracetam (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). In vivo Piracetam (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats. Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats. Piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor in aged mice. Piracetam-treated withdrawn rats has higher the number of synapses than that observed in nonpiracetam-treated and alcohol-fed animals by up to 20%, the mechanisms leading to the synaptic reorganization took place at the mossy fiber level. cell lines： Concentrations： Incubation Time： Powder Purity:≥100% |
| ALogP | -1.312 |
|---|---|
| hba_count | 2 |
| HBD Count | 1 |
| Rotatable Bond | 2 |
| Canonical SMILES | NC(=O)CN1CCCC1=O |
|---|---|
| 分子量 | 142.16 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 58 mg/mL (198.77 mM); Ethanol: 58 mg/mL (198.77 mM); Water: Insoluble; |
|---|---|
| DMSO(mg / mL) Max Solubility | 72 |
| DMSO(mM) Max Solubility | 506.47 |
| Water(mg / mL) Max Solubility | 72 |
| Water(mM) Max Solubility | 506.47 |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Tingting Li, Like Lin, Cong Li, Jingyi Zheng, Bang Chen, Yehua Shen, Difeng Ren. (2023) Amelioration of walnut-derived novel peptides against D-galactose-induced cognitive impairment by modulating the gut microbiota composition. Food & Function, 14 (9): (4228-4241). [PMID:37067262] [10.1039/D2FO03775K] |
| 2. Cui-Mei Liu, Hong-Yuan He, Lin Xu, Zhen-Dong Hua. (2020) New qualitative analysis strategy for illicit drugs using Raman spectroscopy and characteristic peaks method. Drug Testing and Analysis, 13 (3): (720-728). [PMID:33142047] [10.1002/dta.2963] |
| 3. Xiaomeng Xu, Rong Liang, Dongmei Li, Chengyao Jiang, Songyi Lin. (2020) Evaluation of sea cucumber peptides-assisted memory activity and acetylation modification in hippocampus of test mice based on scopolamine-induced experimental animal model of memory disorder. Journal of Functional Foods, 68 (103909). [10.1016/j.jff.2020.103909] |
| 1. Tingting Li, Like Lin, Cong Li, Jingyi Zheng, Bang Chen, Yehua Shen, Difeng Ren. (2023) Amelioration of walnut-derived novel peptides against D-galactose-induced cognitive impairment by modulating the gut microbiota composition. Food & Function, 14 (9): (4228-4241). [PMID:37067262] [10.1039/D2FO03775K] |
| 2. Cui-Mei Liu, Hong-Yuan He, Lin Xu, Zhen-Dong Hua. (2020) New qualitative analysis strategy for illicit drugs using Raman spectroscopy and characteristic peaks method. Drug Testing and Analysis, 13 (3): (720-728). [PMID:33142047] [10.1002/dta.2963] |
| 3. Xiaomeng Xu, Rong Liang, Dongmei Li, Chengyao Jiang, Songyi Lin. (2020) Evaluation of sea cucumber peptides-assisted memory activity and acetylation modification in hippocampus of test mice based on scopolamine-induced experimental animal model of memory disorder. Journal of Functional Foods, 68 (103909). [10.1016/j.jff.2020.103909] |
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