计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 4 篇同行评审文献引用。
概述
用途：
吡拉西坦用于研究6种吡拉西坦共晶体的晶体结构和理化性质。它还用于研究其体外抗氧化特性。
Information
Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
In vitro
Piracetam is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960). Piracetam (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH).
In vivo
Piracetam (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats. Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats. Piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor in aged mice. Piracetam-treated withdrawn rats has higher the number of synapses than that observed in nonpiracetam-treated and alcohol-fed animals by up to 20%, the mechanisms leading to the synaptic reorganization took place at the mossy fiber level.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥100%
规格
英文别名
UCB 6215 | 1-Pyrrolidineacetamide, 2-oxo-
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Piracetam
生化机理
吡拉西坦（UCB 6215）是神经递质γ-氨基丁酸（GABA）的环状衍生物，可用于治疗多种认知障碍。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
变构调节剂
作用机制
GluA1 的受体调节剂;GluA2 的受体调节剂;GluA3 的受体调节剂;GluA4 的受体调节剂
名称和识别符
EC号
231-312-7
分子类型
小分子
Isomeric SMILES
C1CC(=O)N(C1)CC(=O)N
分子量
142.156
Reaxy-Rn
1526393
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1526393&ln=
技术文档
高级数据
关联靶点（人）
GRIA4
Tclin
谷氨酸受体 4(Glutamate receptor 4)
(0 活性数据)
GRIA2
Tclin
谷氨酸受体 2(Glutamate receptor 2)
(0 活性数据)
GRIA3
Tclin
谷氨酸受体 3(Glutamate receptor 3)
(0 活性数据)
GRIA1
Tclin
谷氨酸受体 1(Glutamate receptor 1)
(0 活性数据)
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 58 mg/mL (198.77 mM); Ethanol: 58 mg/mL (198.77 mM); Water: Insoluble;
安全和危险性（GHS）
WGK Germany
2
RTECS
UX9660500
个人防护装备
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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