普罗布考, ATP 结合盒亚族 A 成员 1 抑制剂

低密度脂蛋白调节剂

有货

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货号 (SKU)	包装规格	是否现货	价格	数量
P408795-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	DH-581 \| 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol
规格或纯度	Moligand™, 10mM in DMSO
英文名称	Probucol
生化机理	普罗布考（DH-581）是一种抗高血脂药物，它通过提高低密度脂蛋白的分解率来降低血液中的胆固醇水平。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	ATP 结合盒亚族 A 成员 1 抑制剂
产品介绍	Information Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. In vitro In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

HPN Tchem 丝氨酸蛋白酶 hepsin(Serine protease hepsin) (1 活性数据)

点击查看靶蛋白信息： HPN

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

分子类型	小分子
Canonical SMILES	CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(O)C(=C2)C(C)(C)C)C(C)(C)C
分子量	516.84

溶解性	Solubility (25°C) In vitro

Concentration(Compounding value)	9-11(mmol/L)
Record the entire process by video	Conform

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang. (2023) Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy. Acta Biomaterialia, [PMID:38141933] [10.1016/j.actbio.2023.12.027]
2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang. (2020) Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol. CARBOHYDRATE POLYMERS, 229 (115508). [PMID:31826471] [10.1016/j.carbpol.2019.115508]

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang. (2023) Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy. Acta Biomaterialia, [PMID:38141933] [10.1016/j.actbio.2023.12.027]
2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang. (2020) Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol. CARBOHYDRATE POLYMERS, 229 (115508). [PMID:31826471] [10.1016/j.carbpol.2019.115508]