| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P421257-1ml |
1ml |
现货  |
|
| 别名 | 四氢-4-[[[4-[[[4-[[(3R)-四氢-3-呋喃基]氧基] -1,2-苯并恶唑-3-基]氧基]甲基] -1-哌啶基]甲基]- 2H-吡喃-4-醇 | 4- {4- [4-四氢呋喃-3-基氧基)-苯并[d]异恶唑-3-基氧基甲基]-哌啶-1-基甲基}-四氢吡喃-4-醇 |
|---|---|
| 英文别名 | PF-4995274, TBPT | PF04995274 | PF 04995274 | S0496 | AC-30621 | XI179PG9LV | (R)-4((4-((4-(Tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol | DB12675 | GTPL9059 | (R)-4-((4-(((4-((Tetrahydrofuran-3-yl |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | PF-04995274 |
| 生化机理 | PF-04995274（PF-4995274）是一种强效、高亲和力、口服活性的血清素 4 受体（5-HT4R）部分激动剂，对人 5-HT4A/4B/4D/4E 的 EC50 分别为 0.47 nM、0.36 nM、0.37 nM 和 0.26 nM。至于大鼠 5-HT4S/4L/4E，EC50 分别为 0.59 nM、0.65 nM 和 0.62 nM。PF-04995274 具有脑穿透性，可用于治疗与阿尔茨海默病相关的认知障碍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 5-HT 4 受体激动剂 |
| 产品介绍 |
Information PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist ofserotonin 4 receptor (5-HT4R)with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. Targets human 5-HT4E (Cell-free assay); human 5-HT4B (Cell-free assay); human 5-HT4D (Cell-free assay); human 5-HT4A (Cell-free assay); rat 5-HT4S (Cell-free assay) 32770,0.26 nM(EC50); 0.36 nM(EC50); 0.37 nM(EC50); 0.47 nM(EC50); 0.59 nM(EC50) |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-[[4-[[4-[(3R)-oxolan-3-yl]oxy-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxan-4-ol |
| INCHI | InChI=1S/C23H32N2O6/c26-23(7-12-27-13-8-23)16-25-9-4-17(5-10-25)14-29-22-21-19(30-18-6-11-28-15-18)2-1-3-20(21)31-24-22/h1-3,17-18,26H,4-16H2/t18-/m1/s1 |
| InChi Key | WLLOFQROROXOMO-GOSISDBHSA-N |
| Canonical SMILES | C1CN(CCC1COC2=NOC3=C2C(=CC=C3)OC4CCOC4)CC5(CCOCC5)O |
| Isomeric SMILES | C1COC[C@@H]1OC2=CC=CC3=C2C(=NO3)OCC4CCN(CC4)CC5(CCOCC5)O |
| PubChem CID | 53354764 |
| 分子量 | 432.51 |
| 分子量 | 432.500 g/mol |
|---|---|
| XLogP3 | 2.400 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 432.226 Da |
| 单同位素质量Monoisotopic Mass | 432.226 Da |
| 拓扑极表面积Topological Polar Surface Area | 86.400 Ų |
| 重原子数Heavy Atom Count | 31 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 566.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| RIDADR | NONHforallmodesoftransport |
|---|
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
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